One-pot squaric acid diester mediated aqueous protein conjugation.
نویسندگان
چکیده
A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also tolerates e.g. hydroxyl groups and can also be used for the modification of proteins with water-insoluble amines.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 71 شماره
صفحات -
تاریخ انتشار 2013